| February 25th, 2021 - Axl appears on an episode of Scooby-Doo and Guess Who? on Boomerang. The episode is called Dark Diner of Route 66 and he plays a cartoon version of himself. |
| March 20th, 2021 - Guns N' Roses' Greatest Hits has spent 520 weeks on the Billboard 200 chart. |
| April 3rd, 2021 - The Billboard 200 chart dated April 3rd, 2021 has Guns N' Roses' Greatest Hits album at #75. This means the album has spent a total of 522 weeks on the chart. Which also means that it just passed the ten year mark. |
| April 6th, 2021 - Guns N' Roses announced that their scheduled summer 2021 European tour has been postponed until summer 2022 due to the pandemic. |
| April 16th, 2021 - One of Duff McKagan's previous bands, The Living, released their album 1982. |
| April 21st, 2021 - Guns N' Roses announces that they will return to Vienna, Austria on their 2022 European tour. The show will take place on July 13th, 2022 the Ernst-Happel-Stadion. |
| July 31st, 2021 - Guns N' Roses plays their first show since the pandemic began. The 2021 US tour starts with a show in Hershey, PA at Hersheypark Stadium. The opening act on this tour is Mammoth WVH. |
| August 3rd, 2021 - Show in Boston, MA at the legendary Fenway Park. The band plays Absurd for the first time. The song is eventually released on August 6th. |
| August 5th, 2021 - GN'R returns to East Rutherford, NJ to play at the Metlife Stadium. Axl announces that their new single Absurd will be released at midnight. He also sings a snippet of Just A Friend, and dedicates Knockin' On Heaven's Door to Biz Markie. |
| August 6th, 2021 - Absurd, the first song to be released since Duff and Slash rejoined, is released digitally. |
| August 8th, 2021 - Show in Detroit, MI at Comerica Park. |
| August 11th, 2021 - GN'R plays in Fargo, ND at the FargoDome. The first indoor show of this tour. |
| August 13th, 2021 - The first ever GN'R show in Montana. The show is in Missoula at Grizzly Stadium. There is no opening act after Mammoth WVH had to cancel due to a member of their touring personnel testing positive for COVID-19. |
| August 16th, 2021 - Show in Commerce City, CO at Dick's Sporting Goods Park. The Velveteers open the show. |
| August 19th, 2021 - The Los Angeles, CA show is at the Banc Of California Stadium. Mammoth WVH is back on the tour. |
| August 22nd, 2021 - Show in Portland, OR at the Moda Center. |
| August 25th, 2021 - Northern California show in San Jose, CA at the SAP Center. Axl dedicates the whole show to Charlie Watts. |
| August 27th, 2021 - Guns N' Roses becomes the first rock band to play at the new Allegiant Stadium in Las Vegas, NV. |
| August 30th, 2021 - Show in Phoenix, AZ at the Footprint Center. Axl compliments the crowd for their scream during Welcome To The Jungle. |
| September 1st, 2021 - Show in Dallas, TX at the American Airlines Center. |
| September 4th, 2021 - Guns N' Roses headlines the BottleRock festival held in Napa, CA at the Napa Valley Expo. The band is joined by Pink to perform Patience and Dave Grohl on Paradise City. Due to the curfew, the power is turned off and the end of the song can't be heard by the audience. |
| September 8th, 2021 - Show in Axl's home state, in Indianapolis, IN at Lucas Oil Stadium. |
| September 11th, 2021 - First of two shows in Atlantic City, NJ at Hard Rock Live at Etess Arena. Axl acknowledges the 20th anniversary of 9/11 and dedicate Knockin' On Heaven's Door to the lives lost. |
| September 12th, 2021 - Second show in Atlantic City, NJ at Hard Rock Live at Etess Arena. |
| September 16th, 2021 - Show in "sweet home Chicago" at the legendary Wrigley Field. |
| September 18th, 2021 - Headlining show at Summerfest held in Milwaukee, WI at the American Family Insurance Amphitheater. |
| September 21st, 2021 - Show in St Paul, MN at the Xcel Energy Center. Before Knockin' On Heaven's Door, Axl compliments the audience. |
| September 23rd, 2021 - Show in Columbus, OH at The Schottenstein Center. Axl sings the Addams Family theme as he leaves the stage after Nightrain. |
| September 24th, 2021 - Guns N' Roses released their new single, Hard Skool. |
| September 26th, 2021 - The show in Baltimore, MD at Royal Farms Arena sees the band perform their new single, Hard Skool, for the first time. |
| September 26th, 2021 - It was announced that the scheduled shows in Australia and New Zealand for November, would be postponed until 2022. |
| September 29th, 2021 - Show in Raleigh, NC at the PNC Arena |
| October 2nd, 2021 - First of two nights in Hollywood, FL at The Hard Rock Live at the Seminole Hard Rock. Wolfgang Van Halen joins the band for Paradise City. |
| October 3rd, 2021 - The second of two nights in Hollywood, FL at The Hard Rock Live at the Seminole Hard Rock is also the last show of the 2021 US tour. Before the band introductions Axl thanks the fans and crew for this tour. Just like the previous night, Wolfgang Van Halen joins the band to perform Paradise City. |
| November 21st, 2021 - The show announced for Dunedin, New Zealand to be held at Forsyth Barr Stadium was canceled when the tour was postponed to 2022 due to the pandemic. |
| December 1st, 2021 - It's announced that Guns N' Roses will headline the September 8th, 2022 day at the Rock In Rio festival held in Rio de Janeiro, Brazil. |
| December 3rd, 2021 - The lyric video for the latest Guns N' Roses single, Hard Skool, has its premiere. |
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