I was watching the Vikings Chargers game and right before the half there was a commercial of two people playing guitar hero III and playing, "Slither". During the solo Slash's fist pops through the guys mouth and he pretty much just explodes through his mouth and plays the solo to Slither. At the end the commercial asks, "Is there a guitar hero in you?" I thought it was pretty cool.
this is the one you're talking about?
http://www.xgn.nl/wii/stream/38964/